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Updated: Apr 15, 2026

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Immobilization of fluorescent chemosensor on pyrogenic silica: a promising device for gaseous detection
M Becuwe1, P-E Danjou2, F Cazier2
1Laboratoire de Réactivité et Chimie des Solides, UMR CNRS 7314, Université de Picardie Jules Verne, 33 rue Saint-leu, 80039 Amiens Cedex, France.
Abstract:
A new approach to enhance performances of a cyclodextrin-based fluorescent chemosensor combining grafting on a silica matrix and quaternization reaction is presented. The full characterization of new fluorescent hybrid material has clearly revealed the embedding of cyclodextrin inside the siliceous material. Finally, through a comparison with previous aqueous studies, a preliminary test of toluene detection was presented and highlighted the high potential of this approach, which opens attractive perspectives of evolution toward more sensitive and selective VOC's sensing in air or in hot industrial gaseous waste.
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