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Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A

L Kheirandish-Gozal1, A Gileles-Hillel1, M L Alonso-Álvarez2

  • 1Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.

International Journal of Obesity (2005)
|March 25, 2015
PubMed

Insights

Adenotonsillectomy (T&A) reduced key inflammatory markers in obese children with obstructive sleep apnea syndrome (OSA). This suggests T&A can reverse OSA-related inflammation, potentially mitigating associated health risks.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Immunology

Background:

  • Obesity and obstructive sleep apnea syndrome (OSA) frequently coexist in children.
  • This overlap is linked to systemic inflammation, contributing to end-organ damage.

Purpose of the Study:

  • To investigate the impact of adenotonsillectomy (T&A) on inflammatory markers in obese children diagnosed with OSA.
  • To assess changes in plasma biomarkers following T&A in this pediatric population.

Main Methods:

  • Prospective study of obese children with polysomnographically diagnosed OSA undergoing T&A.
  • Collection of plasma samples pre- and post-T&A for analysis of inflammatory and metabolic markers.
  • Evaluation of polysomnography (PSG) results before and after T&A.

Main Results:

  • One-third of children showed normalized PSG after T&A (AHI ≤1/hour).
  • Significant decreases observed in MCP-1, PAI-1, MMP-9, IL-18, and IL-6 post-T&A.
  • Increases noted in adropin and osteocrin plasma levels after T&A.

Conclusions:

  • Obstructive sleep apnea syndrome in obese children is associated with reversible alterations in systemic inflammatory and metabolic biomarkers.
  • These findings support the pro-inflammatory interplay between OSA and obesity, impacting long-term health.
  • T&A may offer a therapeutic strategy to modulate these biomarkers and reduce associated morbidities.
Abstract

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