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RNA-stabilizing proteins as molecular targets in cardiovascular pathologies
Sahana Suresh Babu1, Darukeshwara Joladarashi1, Prince Jeyabal1
1Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX.
Trends in Cardiovascular Medicine
|March 25, 2015
Summary
RNA stabilizing proteins (RSPs) regulate gene expression and cellular homeostasis. This review explores their role in cardiovascular diseases like myocardial infarction, hypertension, and hypertrophy, highlighting therapeutic potential.
Area of Science:
- Molecular Biology
- Gene Regulation
- Cardiovascular Science
Background:
- mRNA stability is crucial for eukaryotic gene expression and cellular homeostasis.
- RNA stabilizing proteins (RSPs) bind to specific mRNA elements, affecting stability and translation.
- Dysregulation of RSPs links cellular states to disease, acting as a molecular switch.
Purpose of the Study:
- To review the emerging role of RSPs in cardiovascular pathologies.
- To specifically examine HuR-mediated mRNA stability in myocardial infarction, hypertension, and hypertrophy.
- To discuss the clinical implications of RSPs as therapeutic targets in cardiovascular diseases.
Main Methods:
- Literature review of studies on RSPs and cardiovascular diseases.
- Analysis of RSP involvement in cellular processes relevant to cardiovascular health (inflammation, fibrosis, angiogenesis, cell death, proliferation).
- Synthesis of current understanding of HuR's role in specific cardiovascular conditions.
Main Results:
- RSPs, particularly HuR, influence key cellular processes implicated in cardiovascular disease.
- Evidence suggests a significant role for RSPs in myocardial infarction, hypertension, and hypertrophy.
- RSPs modulate inflammation, fibrosis, angiogenesis, cell death, and proliferation in cardiovascular contexts.
Conclusions:
- RSPs, especially HuR, are critical regulators in cardiovascular pathophysiology.
- Understanding RSP function offers insights into cardiovascular disease mechanisms.
- RSPs represent promising therapeutic targets for cardiovascular disease treatment.
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