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Immunogenicity of β-cells for autologous transplantation in type 1 diabetes

Christian Schuetz1, James F Markmann1

  • 1Islet Transplantation Laboratory, Division of Transplantation, Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Thier 825, Boston, MA 02114, United States.

Pharmacological Research
|March 25, 2015
PubMed

The success of clinical islet transplantation calls for a broader application of this curative treatment for type 1 diabetes mellitus. The toxicity of immunosuppression, limited organ donor supply and high procedural costs are deterrents to expand this therapy to patients with uncomplicated diabetes. The use of pancreatic β-cell like cells derived from the patient's own induced pluripotent cells (iPSC) holds potential to overcome these barriers. In this review, we discuss the practicality of this regenerative medicine approach and existing evidence regarding the true immunogenicity of iPSC derived cells.

Keywords:
Immune toleranceImmunogenicityInduced pluripotent stem cellsIslet transplantationPancreatic beta cellsType 1 diabetes mellitus

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