Related Experiment Video

Updated: Apr 15, 2026

Wolbachia Bacterial Infection in Drosophila
09:46

Wolbachia Bacterial Infection in Drosophila

Published on: February 25, 2007

8.0K

Introduction to a thematic issue for WWOX

Nan-Shan Chang1

  • 1Experimental Biology and Medicine, Institute of Molecular Medicine, National Cheng Kung University, Tainan, 70101 Taiwan; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY, 13210 USA; Department of Neurochemistry, NYS Institute of Basic Research for Developmental Disabilities, Staten Island, NY, 10314 USA changns@mail.ncku.edu.tw.

Experimental Biology and Medicine (Maywood, N.J.)
|March 25, 2015
PubMed

Insights

WW domain-containing oxidoreductase (WWOX) is not a cancer driver but is crucial for neural health. Mutations cause severe neural pathologies, highlighting WWOX

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • WW domain-containing oxidoreductase (WWOX) has been primarily studied as a tumor suppressor.
  • Research has focused on its role in cancer initiation and progression.

Discussion:

  • WWOX is not a driver of cancer initiation; chromosomal alterations in its gene promote cancer progression.
  • Homozygous nonsense mutations in WWOX cause severe neural pathologies and early death in humans, not cancer.
  • This suggests critical physiological roles for WWOX beyond tumor suppression, particularly in metabolism and neural function.

Key Insights:

  • WWOX's established tumor suppressor role requires re-evaluation.
  • WWOX is essential for preventing neural pathologies and ensuring normal metabolism.
  • Genetic alterations in WWOX have distinct consequences for cancer versus neurological health.

Outlook:

  • Further investigation into WWOX's functions in metabolism and neural diseases is warranted.
  • Understanding WWOX's signaling pathways may reveal new therapeutic targets for neurodegenerative disorders.
  • Exploring WWOX interactions with oncogenic viruses could offer insights into viral pathogenesis.
Keywords:
FORWOX1WWOXcancermetabolismneural diseases

More Related Videos

Author Spotlight: Analysis of Ovarian Anatomy in Migratory Insects to Overcome Experimental Challenges04:41

Author Spotlight: Analysis of Ovarian Anatomy in Migratory Insects to Overcome Experimental Challenges

Published on: July 14, 2023

2.4K
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

1.2K

Related Concept Videos

Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
2.5K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.6K
Threats to Biodiversity01:50

Threats to Biodiversity

There have been five major extinction events throughout geological history, resulting in the elimination of biodiversity, followed by a rebound of species that adapted to the new conditions. In the current geological epoch, the Holocene, there is a sixth extinction event in progress. This mass extinction has been attributed to human activities and is thus provisionally called the Anthropocene. In 2019 the human population reached 7.7 billion people and is projected to comprise 10 billion by...
27.9K
Thematic Layering in GIS01:30

Thematic Layering in GIS

In the past, planning projects such as schools or public facilities required extensive manual effort to gather and compile data. Information such as property boundaries, soil characteristics, road networks, zoning regulations, and flood zones had to be sourced individually from courthouses, utility providers, and registry offices. Assembling these datasets into a coherent format often took several months, delaying project timelines.The introduction of Geographic Information Systems (GIS)...
440
Oxidative Cleavage of Alkenes: Ozonolysis01:46

Oxidative Cleavage of Alkenes: Ozonolysis

In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
13.9K
Eccentric Axial Loading in a Plane of Symmetry01:16

Eccentric Axial Loading in a Plane of Symmetry

Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.
728