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Cardiovascular complications secondary to Graves' disease: a prospective study from Ukraine

Iryna Tsymbaliuk1, Dmytro Unukovych2, Nataliia Shvets1

  • 1Department of Therapy, Shupyk National Medical Academy of Postgraduate Education, 04112 Kiev, Ukraine; Department of Functional Diagnostic, Kyiv City Teaching Endocrinological Center, 01034 Kiev, Ukraine.

Plos One
|March 25, 2015
PubMed

Insights

Restoring euthyroid state in Graves' disease patients significantly reduces cardiovascular issues and improves quality of life. This study highlights the positive impact of thyroid normalization on thyrotoxic heart disease patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Quality of Life Research

Background:

  • Graves' disease (GD) is a leading cause of hyperthyroidism.
  • Hyperthyroidism can lead to thyrotoxic heart disease (THD).

Purpose of the Study:

  • To assess cardiovascular complications in patients with THD secondary to GD.
  • To evaluate health-related quality of life (HRQoL) in these patients.

Main Methods:

  • Clinical assessment of 61 patients with THD secondary to GD before and after achieving a euthyroid state.
  • HRQoL assessment using the EQ-5D-5L questionnaire in 30 patients.
  • Statistical analysis to determine the impact of treatment on cardiovascular parameters and HRQoL.

Main Results:

  • Significant reductions in resting heart rate, blood pressure, atrial fibrillation, congestive heart failure, and thyrotoxic cardiomyopathy after treatment (p<0.01).
  • Anti-TSH receptor antibodies identified as predictors of left ventricular geometry changes (p=0.02).
  • HRQoL domains and self-rated health significantly improved (p<0.001).

Conclusions:

  • Achieving a euthyroid state in GD patients effectively eliminates cardiovascular disorders.
  • Treatment of THD secondary to GD substantially enhances patient HRQoL.
  • This study provides novel insights into HRQoL among Ukrainian patients with THD secondary to GD.
Abstract

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