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Altered cardiovascular autonomic function in young normotensive offspring of hypertensive parents - Is obesity an

Selvaraj Smilee Johncy, Challakere Subramanya Karthik, Suresh Yankanna Bondade

    Journal of Basic and Clinical Physiology and Pharmacology
    |March 25, 2015
    PubMed

    Insights

    Obesity in children of hypertensive parents significantly alters autonomic nervous system (ANS) function, increasing hypertension risk. These findings highlight obesity as a critical risk factor in offspring of hypertensive parents.

    Area of Science:

    • Cardiology
    • Autonomic Nervous System Research
    • Hypertension Studies

    Background:

    • Early identification of cardiovascular risk factors in offspring of hypertensive parents is crucial.
    • Obesity is a known risk factor for hypertension, but its specific impact on autonomic function in at-risk youth requires further investigation.

    Purpose of the Study:

    • To analyze autonomic dysregulation in normotensive offspring of hypertensive parents.
    • To determine if obesity exacerbates autonomic dysregulation and increases future hypertension risk in this population.

    Main Methods:

    • Compared heart rate variability (HRV) indices in normotensive obese and non-obese offspring of hypertensive parents versus a control group.
    • Utilized anthropometric measurements, blood pressure, and heart rate recordings.
    • Employed statistical analyses including ANOVA and Pearson correlation.

    Main Results:

    • Obese offspring with hypertensive parents exhibited higher heart rate, diastolic blood pressure, and sympathetic (LF, LF/HF) HRV indices.
    • Reduced parasympathetic (HF, SDNN, RMSSD, PNN50%) HRV indices were observed in this group.
    • Body Mass Index (BMI) showed a negative correlation with parasympathetic HRV and a positive correlation with sympathetic HRV.

    Conclusions:

    • Obesity significantly dysregulates autonomic control in offspring of hypertensive parents, characterized by reduced vagal dominance and increased sympathetic activity.
    • Obesity acts as an additional risk factor for future hypertension by further impairing cardiac autonomic control in at-risk individuals.
    Abstract

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