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Quantitative photoacoustic tomography using illuminations from a single direction.

Aki Pulkkinen1, Ben T Cox2, Simon R Arridge3

  • 1University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, 70211 Kuopio, Finland.

Journal of Biomedical Optics
|March 25, 2015
PubMed
Summary

Quantitative photoacoustic tomography can use spatially modulated illumination from one side to estimate optical parameters. This method aids in distinguishing near-surface inclusions but has limited imaging depth compared to multi-directional approaches.

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Area of Science:

  • Biomedical imaging
  • Optical physics
  • Inverse problems

Background:

  • Quantitative photoacoustic tomography (QPAT) estimates optical parameters in tissues using photoacoustic images.
  • Estimating multiple optical parameters is often non-unique without varied illumination.
  • Multi-directional illumination is typically used, but not always feasible for thick samples.

Purpose of the Study:

  • To investigate the use of spatially modulated illumination from a single direction for QPAT.
  • To determine if this approach can overcome the non-uniqueness problem in optical parameter estimation.
  • To assess the feasibility of imaging absorption and scattering inclusions.

Main Methods:

  • Simulations were performed to evaluate spatially modulated illumination patterns.
  • The technique was tested for its ability to provide multiple effective illuminations.
  • The capability to distinguish between absorption and scattering inclusions was analyzed.

Main Results:

  • Spatially modulated illumination from one side can provide multiple illuminations for QPAT.
  • The approach successfully distinguishes absorption and scattering inclusions near the surface.
  • Imaging depth is limited compared to full multi-directional illumination setups.

Conclusions:

  • Single-direction spatially modulated illumination is a viable alternative for QPAT in specific scenarios.
  • This method offers a potential solution when multi-directional illumination is impractical.
  • Further research may be needed to improve imaging depth for deeper tissues.