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Updated: Apr 15, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
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Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes

Sarah A Tersey1, Esther Bolanis1, Theodore R Holman1

  • 1Departments of Pediatrics and the Center for Diabetes and Metabolic Diseases (S.A.T., R.G.M.), Biochemistry and Molecular Biology (E.B., R.G.M.), Medicine (R.G.M.), and Cellular and Integrative Physiology (R.G.M.), Indiana University School of Medicine, Indianapolis, Indiana 46202; Department of Chemistry and Biochemistry (T.R.H.), University of California, Santa Cruz, Santa Cruz, California 95064; National Center for Advancing Translational Sciences (D.J.M.), National Institutes of Health, Rockville, Maryland 20850; and Department of Medicine and the Strelitz Diabetes Center (J.L.N.), Eastern Virginia Medical School, Norfolk, Virginia 23507.

Molecular Endocrinology (Baltimore, Md.)
|March 25, 2015
PubMed
Summary

Inflammation damages insulin-producing islet beta-cells in diabetes. Inhibiting the enzyme 12-lipoxygenase (12-LO) shows promise for preventing and treating metabolic diseases by reducing this inflammation.

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