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Updated: Apr 15, 2026
09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
22.8K
[Chronic lymphocytic leukemia accompanied by renal failure]
Terapevticheskii Arkhiv
|March 26, 2015
Summary
Bendamustine (B) plus rituximab (R) showed high efficacy in chronic lymphocytic leukemia (CLL) patients with renal failure (RF). Bendamustine monotherapy also improved kidney function without nephrotoxicity, indicating its safety in this population.
Area of Science:
- Hematology
- Nephrology
- Clinical Oncology
Background:
- Chronic lymphocytic leukemia (CLL) often co-occurs with renal failure (RF).
- Evaluating treatment efficacy and safety in CLL patients with RF is crucial.
Purpose of the Study:
- To assess the effectiveness and safety of bendamustine (B) monotherapy and bendamustine plus rituximab (B + R) combination therapy.
- To evaluate these therapies in patients with CLL and concurrent renal failure.
Main Methods:
- A prospective pilot study involving 8 patients with CLL and RF.
- Patients received either B monotherapy (n=5) or B + R combination therapy (n=3).
- Evaluated treatment efficiency, safety, and impact on renal function (creatinine, GFR).
Main Results:
- B + R therapy achieved complete remission in all 3 patients.
- B monotherapy resulted in complete remission in 1/5, partial remission in 3/5, and nodular partial remission in 1/5.
- Both therapies improved kidney function, with decreased creatinine and increased GFR, showing no nephrotoxic effects.
Conclusions:
- Bendamustine plus rituximab combination therapy is effective for CLL patients with renal failure.
- Bendamustine monotherapy demonstrated improved renal function and was not nephrotoxic.
- These findings support the use of B and B + R in CLL patients with renal impairment.
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