Photic responses of the retina at different ages: a comparative study using histochemical and biochemical methods

The alkaline phosphatase and DNA-RNA activities in the retinas of young and old albino mice were determined histochemically after photic exposure. Different patterns between the two age groups were obtained for the alkaline phosphatase reaction before and after photic exposure. In the young animals, more retinal layers showed increased activity after exposure whereas in the old animals, the converse was true. DNA-RNA reaction also revealed decreased DNA activities in the old animals 30 h after exposure. The results were also correlated with biochemical studies on 2-deoxyglucose, dopamine and leucine uptakes.