Lentiviral vectors in cancer immunotherapy

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Robyn Aa Oldham1, Elliot M Berinstein, Jeffrey A Medin

  • 1Department of Medical Biophysics, University of Toronto, 27 King's College Circle, Toronto, ON M5S, Canada.

Immunotherapy
|March 26, 2015
PubMed

Insights

Lentiviral vectors offer a safer and more effective gene delivery method for cancer immunotherapy. These viral vectors are being explored in clinical trials for various cancers, improving targeted cell modification and immune responses.

Area of Science:

  • Oncology
  • Immunology
  • Gene Therapy
  • Virology

Background:

  • Cancer immunotherapy has advanced significantly, with gene-based therapies showing clinical success.
  • Current gene therapies often involve direct gene insertion for cell killing or immune stimulation.
  • Early gene delivery methods using gamma-retroviruses raised safety concerns due to insertional mutagenesis.

Purpose of the Study:

  • To review current knowledge on lentiviral vectors (LVs).
  • To discuss the application of LVs in cancer immunotherapy.
  • To highlight LVs as a safer alternative for gene delivery in cancer treatment.

Main Methods:

  • Review of existing scientific literature on lentiviral vectors and cancer immunotherapy.
  • Analysis of clinical trial data and research findings related to LV applications.
  • Discussion of the mechanisms and safety profiles of LVs compared to other vectors.

Main Results:

  • Lentiviral vectors are identified as a promising alternative to gamma-retroviruses for gene delivery.
  • LVs demonstrate potential for safer and more effective gene insertion.
  • LVs are currently utilized in clinical trials for diverse disorders, including cancer.

Conclusions:

  • Lentiviral vectors represent a significant advancement in gene delivery for cancer immunotherapy.
  • Their improved safety and efficacy profile make them suitable for clinical applications.
  • Further research and clinical trials are expected to expand the role of LVs in treating cancer.
Keywords:
T cellscancercell-fate control systemcellular immunitychimeric antigen receptorcytokinesdendritic cellsimmunotherapylentivirustransgene

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