Related Experiment Video
Updated: Apr 15, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Short-term comparison of accelerated and standard methods of corneal collagen crosslinking
Hassan Hashemi1, Akbar Fotouhi1, Mohammad Miraftab1
1From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
Purpose:
To compare the 6-month results of accelerated and standard collagen crosslinking (CXL) treatment of progressive keratoconus.
Setting:
Noor Eye Hospital, Tehran, Iran.
Design:
Prospective randomized clinical trial.
Methods:
Two groups of eyes (intervention and control) received corneal collagen crosslinking (CXL) treatment. The intervention group received accelerated CXL (18 mW/cm(2), 5 minutes), and the control group received standard CXL (3 mW/cm(2), 30 minutes). The eyes were evaluated for changes in the visual indices, refraction, and topography preoperatively and 1, 3, and 6 months postoperatively and regarding corneal rigidity indices and the endothelial cell count (ECC) preoperatively and at 6 months.
Results:
The study evaluated 62 eyes (31 patient) in 2 groups. The mean changes in uncorrected (P = .733) and corrected (P = .646) distance visual acuities and manifest refraction spherical equivalent (P = .598) did not differ statistically significantly between the 2 groups. The central corneal thickness was higher in the standard group than the accelerated group (P = .025). The mean decrease in the maximum keratometry (K) (P = .865) and mean K (P = .974) and the mean changes in the asphericity (P = .272) were not statistically significantly different between the 2 groups. The mean changes in corneal hysteresis (CH) (P = .548) and the corneal resistance factor (CRF) (P = 1.000), CH-CRF (P = .282), and the area under the peak 2 (P = .260) were similar in both groups. The mean decrease in the ECC was not statistically significantly different between the 2 groups (P = .218).
Conclusion:
Based on 6-month results, accelerated and standard corneal CXL arrested the progression of keratoconus similarly.
Financial Disclosure:
No author has a financial or proprietary interest in any material or method mentioned.
More Related Videos
12:25Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
Published on: January 6, 2018
05:56Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016