Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

170
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
170

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tertiary Amides as Directing Groups for Enantioselective C-H Amination using Ion-Paired Rhodium Complexes.

Angewandte Chemie (International ed. in English)·2024
Same author

The evolution of hydrated lime-based cementitious waste forms during leach testing leading to enhanced technetium retention.

Journal of hazardous materials·2022
Same author

Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation.

Journal of the American Chemical Society·2021
Same author

<i>Para</i>-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation.

Journal of the American Chemical Society·2019
Same author

"Misleading falsehoods" regarding assisted dying?

BMJ (Clinical research ed.)·2014
Same author

Performance of the Fluidized Bed Steam Reforming product under hydraulically unsaturated conditions.

Journal of environmental radioactivity·2013
Same journal

Doctors are fighting to protect children from mouldy homes after death of Awaab Ishak.

BMJ (Clinical research ed.)·2026
Same journal

Delayed discharges: Annual cost rises to almost £2.7bn in past year.

BMJ (Clinical research ed.)·2026
Same journal

The UK's social media ban is a gamble in the face of uncertainty.

BMJ (Clinical research ed.)·2026
Same journal

Wegovy weight loss pill now available to UK patients-how will it affect doctors?

BMJ (Clinical research ed.)·2026
Same journal

Endometriosis: "Game changing" new tests may speed up diagnosis in primary care.

BMJ (Clinical research ed.)·2026
Same journal

Consultants vote for industrial action in England.

BMJ (Clinical research ed.)·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay
19:34

Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay

Published on: April 3, 2009

45.4K

Problems with using numbers needed to harm

Benjamin D Williams1

  • 1University of Manchester, Manchester M13 9PL, UK benjamin.williams-4@postgrad.manchester.ac.uk.

BMJ (Clinical Research Ed.)
|March 26, 2015
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

13.3K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

953

Related Experiment Videos

Last Updated: Apr 15, 2026

Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay
19:34

Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay

Published on: April 3, 2009

45.4K
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

13.3K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

953