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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Problems with using numbers needed to harm

Benjamin D Williams1

  • 1University of Manchester, Manchester M13 9PL, UK benjamin.williams-4@postgrad.manchester.ac.uk.

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No abstract available in PubMed .

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