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Updated: Apr 15, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study.

Jan Jaap Aten1, Mardien Oudega, Eric van Exel

  • 1Department of Psychiatry, Rijnstate Hospital, P.O. Box 9555, 6800, TA, Arnhem, The Netherlands, jjaten@gmail.com.

European Archives of Psychiatry and Clinical Neuroscience
|March 26, 2015
PubMed
Summary
This summary is machine-generated.

Electroconvulsive therapy (ECT) dosing methods, dose titration (DTM) and age-based (ABM), showed similar outcomes for depression and cognition. However, ABM required fewer ECT sessions than DTM, and older patients needed shorter treatment courses.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Medicine

Background:

  • Electroconvulsive therapy (ECT) is a treatment for severe depression.
  • Current dosing methods include formula-based and individualized approaches.
  • Dose titration method (DTM) is proposed as a more accurate, individualized alternative to formula-based methods.

Purpose of the Study:

  • To compare a repeated dose titration method (DTM) with an age-based method (ABM) for electroconvulsive therapy (ECT).
  • To evaluate differences in treatment characteristics, clinical outcomes, and cognitive functioning between DTM and ABM.

Main Methods:

  • A comparative cohort study involving 39 patients treated with repeated DTM and 40 patients treated with ABM for unipolar depression.
  • Assessment of depression using Montgomery-Åsberg Depression Rating Scale (MADRS) and cognition using Mini-Mental State Examination (MMSE).
  • Analysis of total ECT session numbers and regression analysis to identify factors associated with treatment duration.

Main Results:

  • Both DTM and ABM demonstrated comparable clinical outcomes in depression (MADRS scores) and cognitive functioning (MMSE scores).
  • The median number of ECT sessions was significantly higher in the DTM group (16 sessions) compared to the ABM group (12 sessions).
  • Regression analysis indicated that the ABM dosing method and higher patient age were independently associated with a reduced number of ECT sessions.

Conclusions:

  • Age-based dosing and dose titration methods yield similar efficacy and cognitive safety in ECT for depression.
  • Repeated DTM may lead to longer ECT treatment courses compared to ABM.
  • Older age is a significant factor in reducing the required number of ECT sessions, irrespective of the dosing strategy.