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Updated: Apr 15, 2026

Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Novel targeted therapies in diffuse large B-cell lymphoma
Neha Mehta-Shah1, Anas Younes1
1Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, NY.
Abstract:
Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin's lymphoma. Next-generation sequencing techniques have improved our understanding of the molecular pathways that may drive oncogenesis. Many novel classes of drugs are in development that may improve the treatment of DLBCL, either as single agents or in combination, that exploit their synergy to overcome resistance. We review the key novel targets and therapeutics in the treatment of DLBCL, including immunomodulatory agents and immunotherapy.
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