Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

71
Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
71
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

5.3K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
5.3K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.9K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.9K
Erythropoiesis01:14

Erythropoiesis

7.0K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
7.0K
Ferromagnetism01:31

Ferromagnetism

3.6K
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
3.6K
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

6.2K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neopterin Levels in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: A Potential Biomarker for Acute Graft-Versus-Host Disease?

Transplantation proceedings·2026
Same author

The role of eosinophil counts and megakaryocyte nuclei for distinction of acute and chronic immune thrombocytopenic purpura.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2024
Same author

Life-Threatening Recurrence of Paroxysmal Cold Hemoglobinuria in a Child During Influenza A Infection.

Turkish archives of pediatrics·2024
Same author

Identification of novel antiplatelet agents by targeting Glycoprotein VI: A combined virtual screening study.

Bioorganic chemistry·2022
Same author

COVID-19-associated multisystem inflammatory syndrome in children: Experiences of three centres in Turkey.

Modern rheumatology·2021
Same author

Risk Factors for Graft-Versus-Host Disease and Survival in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Single-Center Experience.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2021

Related Experiment Video

Updated: Apr 15, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K

Iron-refractory iron deficiency anemia.

Ebru Yılmaz Keskin1, İdil Yenicesu

  • 1Samsun Education and Research Hospital, Clinic of Pediatric Hematology and Oncology, Samsun, Turkey.

Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology
|March 26, 2015
PubMed
Summary

Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by TMPRSS6 mutations, leading to inappropriately high hepcidin levels and resistance to iron therapy. Understanding IRIDA improves treatment for rare anemias.

More Related Videos

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example
12:44

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example

Published on: December 3, 2014

55.2K
A Colorimetric Method for Measuring Iron Content in Plants
07:12

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

23.2K

Related Experiment Videos

Last Updated: Apr 15, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K
Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example
12:44

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example

Published on: December 3, 2014

55.2K
A Colorimetric Method for Measuring Iron Content in Plants
07:12

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

23.2K

Area of Science:

  • Hematology
  • Genetics
  • Molecular Biology

Background:

  • Iron is vital for biological processes including oxygen transport and DNA synthesis.
  • Iron metabolism regulation is complex and crucial for maintaining homeostasis.
  • Genetic disorders like hemochromatosis and IRIDA offer insights into iron regulation.

Purpose of the Study:

  • To review current knowledge on Iron-Refractory Iron Deficiency Anemia (IRIDA).
  • To increase awareness of IRIDA among healthcare professionals.
  • To highlight the genetic basis and clinical features of IRIDA.

Main Methods:

  • Review of existing literature on IRIDA.
  • Analysis of genetic mutations in TMPRSS6 (encoding matriptase-2).
  • Comparison of clinical and laboratory findings in IRIDA versus classic iron deficiency anemia.

Main Results:

  • IRIDA is caused by TMPRSS6 mutations, affecting hepcidin regulation.
  • Patients present with hypochromic, microcytic anemia, low transferrin saturation, and poor response to oral iron.
  • Serum ferritin is typically low-normal, with inappropriately high hepcidin levels relative to anemia severity.

Conclusions:

  • IRIDA is the most common atypical microcytic anemia, despite its rarity.
  • Understanding TMPRSS6 mutations and hepcidin regulation is key to diagnosing and managing IRIDA.
  • Advances in understanding IRIDA can inform treatments for various iron metabolism disorders.