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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Related Experiment Video

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Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
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Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone.

Guy Barry1, Boris Guennewig1, Samantha Fung2

  • 1Garvan Institute of Medical Research , Sydney, NSW , Australia ; St Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.

Frontiers in Neurology
|March 26, 2015
PubMed
Summary

Adult human brain

Keywords:
aginginterneuronlong non-coding RNAneurodevelopmental diseaseneurogenesissubependymal zone

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Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • The human subependymal zone (SEZ) is a potential source of new neurons throughout life.
  • Neurogenesis involves complex gene expression changes, including non-coding RNAs.
  • Understanding SEZ transcriptomics is crucial for adult neurogenesis research.

Purpose of the Study:

  • To comprehensively analyze the transcriptional landscape of the adult human SEZ.
  • To identify unique transcripts, particularly long non-coding RNAs (lncRNAs), in the SEZ.
  • To investigate age-related changes in SEZ gene expression.

Main Methods:

  • Deep RNA sequencing of adult and aging human SEZ tissue.
  • Transcriptomic analysis focusing on messenger RNAs (mRNAs) and lncRNAs.
  • Identification and characterization of highly expressed SEZ-specific lncRNAs.

Main Results:

  • Identified age-related changes in mRNAs related to proliferation, progenitor cells, and inflammation.
  • Discovered a unique set of highly expressed lncRNAs in the human SEZ, many with unknown functions.
  • Confirmed robust proliferative and neuronal differentiation potential in the adult human SEZ.

Conclusions:

  • The adult human SEZ exhibits significant proliferative and neuronal differentiation capabilities.
  • A distinct set of lncRNAs are highly expressed in the SEZ, suggesting novel roles in brain function.
  • This study provides a foundation for exploring lncRNA involvement in postnatal neurogenesis and neurodevelopmental diseases.