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Immune therapy of metastatic melanoma developing after allogeneic bone marrow transplant

Michael Cecchini1, Mario Sznol1, Stuart Seropian1

  • 1Division of Medical Oncology, Yale Cancer Center, Smilow Cancer Hospital of the Yale-New Haven Hospital Yale University School of Medicine, New Haven, USA.

Journal for Immunotherapy of Cancer
|March 26, 2015
PubMed

Metastatic melanoma is frequently treated with immune activating therapy, which poses a theoretical risk of inducing graft versus host disease (GVHD) in those who have received allogeneic stem cell transplantation. The literature reporting the safety of immunotherapy in post transplant patients is limited. We report two patients with metastatic melanoma who received treatment with immunotherapy after allogeneic stem cell transplantation that did not result in GVHD.

Keywords:
Allogeneic transplantCTLA-4 antigenGraft vs host diseaseImmunotherapyInterleukin-2IpilimumabMelanomaProgrammed cell death 1 receptor and immune-related adverse events

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