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Circulating soluble intercellular adhesion molecule-1 in lung cancer: a systematic review
Xiaoling Gu1, Chunyan Ma1, Dongmei Yuan1
1Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in lung cancer patients compared to healthy individuals. This biomarker shows potential for diagnosing lung cancer and predicting patient outcomes.
Area of Science:
- Oncology
- Immunology
- Biomarker Discovery
Background:
- Soluble intercellular adhesion molecule-1 (sICAM-1) is linked to tumor progression and metastasis.
- The diagnostic and prognostic significance of circulating sICAM-1 in lung cancer is not well-established.
Purpose of the Study:
- To review the expression of sICAM-1 in lung cancer patients.
- To evaluate the diagnostic and prognostic value of sICAM-1 in lung cancer.
Main Methods:
- Systematic literature search of electronic databases (PubMed, Web of Science, Medline).
- Meta-analysis of 16 eligible studies including 1258 patients.
- Analysis of sICAM-1 levels in relation to clinical parameters and patient outcomes.
Main Results:
- Lung cancer patients exhibited significantly higher circulating sICAM-1 levels than healthy controls.
- Baseline sICAM-1 levels correlated with ECOG performance status, gender, histology, and disease stage.
- sICAM-1 levels showed an inverse association with prognosis and response rate in non-small cell lung cancer (NSCLC) patients.
Conclusions:
- sICAM-1 is a potential diagnostic biomarker for lung cancer.
- sICAM-1 may serve as a prognostic biomarker for lung cancer patients.
- Further prospective studies are needed to validate these findings.
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