Related Experiment Video

Updated: Apr 15, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.8K

Hippo/YAP pathway for targeted therapy

Emanuela Felley-Bosco1, Rolf Stahel1

  • 1Laboratory of Molecular Oncology, Clinic of Oncology, University Hospital of Zürich, Häldeliweg 4, 8044 Zürich, Switzerland.

Translational Lung Cancer Research
|March 26, 2015
PubMed

Insights

Malignant pleural mesothelioma (MPM) is linked to NF2 gene mutations, impacting the Hippo pathway and Yes Associated Protein (YAP) activity. Therapies targeting YAP offer new treatment avenues for this asbestos-related cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Malignant pleural mesothelioma (MPM) is characterized by genetic alterations, notably in the neurofibromin 2 (NF2) gene.
  • NF2 mutations disrupt the Hippo pathway, leading to dysregulated Yes Associated Protein (YAP) activity.

Purpose of the Study:

  • To explore the molecular underpinnings of MPM, focusing on the NF2-Hippo-YAP signaling axis.
  • To identify novel therapeutic targets by understanding YAP's role in MPM pathogenesis.

Main Methods:

  • Analysis of genetic mutations in NF2 and their impact on Hippo pathway signaling.
  • Investigating the role of YAP as a transcription co-activator for TEAD transcription factors.
  • Reviewing emerging therapeutic strategies targeting YAP signaling.

Main Results:

  • Loss of NF2 function in MPM leads to increased expression of cell cycling genes, such as survivin.
  • YAP activation, driven by NF2 loss, promotes tumor cell proliferation.
  • Several pathways, including hedgehog, and agents like verteporfin, modulate YAP activity.

Conclusions:

  • Targeting the YAP signaling pathway presents a promising therapeutic strategy for malignant pleural mesothelioma.
  • Interference with YAP-TEAD complex formation or its upstream activators (e.g., LPA, thrombin receptors) could be effective treatments.
Keywords:
Hippo pathwayYes associated protein (YAP) oncogenemalignant pleural mesothelioma (MPM)

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

7.5K
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

1.1K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
94
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
11.9K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.4K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

1.9K