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Mean platelet volume in children with Reye-like syndrome

Ahmet Sert1, Cengizhan Kilicaslan, Ece Selma Solak

  • 1Department of Pediatric Cardiology , Konya , Turkey .

Platelets
|March 26, 2015
PubMed

Insights

Mean platelet volume (MPV) is lower in children with Reye-like syndrome (RLS) during early illness stages. MPV levels increase and inflammatory markers decrease following treatment in RLS patients.

Area of Science:

  • Pediatrics
  • Hematology
  • Immunology

Background:

  • Reye-like syndrome (RLS) is a systemic disorder linked to cytokine storm.
  • Mean platelet volume (MPV) reflects platelet production and activation.
  • MPV is a potential biomarker for inflammatory conditions.

Purpose of the Study:

  • To investigate Mean platelet volume (MPV) in pediatric Reye-like syndrome (RLS).
  • To assess MPV changes in RLS patients before and after treatment.

Main Methods:

  • Compared MPV in 30 children with RLS to 30 healthy controls.
  • Analyzed white blood cell (WBC) count, AST, ALT, ESR, and C-reactive protein.
  • Evaluated MPV and inflammatory markers pre- and post-treatment.

Main Results:

  • Children with RLS showed significantly lower MPV compared to controls.
  • Elevated WBC, AST, and ALT were observed in RLS patients.
  • Post-treatment, MPV increased while ESR, C-reactive protein, AST, and ALT decreased.
  • MPV negatively correlated with ESR and WBC.

Conclusions:

  • Lower MPV at early stages may indicate RLS.
  • MPV changes correlate with treatment response in RLS.
  • MPV serves as a potential indicator in RLS management.

Keywords:
Mean platelet volumeReye-like syndromeplatelets

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