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Updated: Apr 15, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Sex differences in N-palmitoylethanolamide effectiveness in neuropathic pain associated with lumbosciatalgia
Carles Morera1, Santiago Sabates, Angeles Jaen
1Cirurgia Ortopèdica i Traumatologia de Catalunya, COTCAT, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Barcelona, Spain.
Background:
Response to N-palmitoylethanolamide (PEA) appear to be influenced by hormonal changes.
Objective:
To evaluate sex differences in the effectiveness of PEA.
Method:
Patients with neuropathic pain resulting from lumbosciatalgia were assigned to conventional treatment plus PEA or conventional treatment. The pain variables were measured using a visual analog scale and quality of life was assessed.
Results:
One hundred and twelve patients were included. Significant differences were seen in men for all the variables. In women the differences were only significant for pain. A multivariate linear regression analysis showed a positive interaction between men and PEA treatment for the SF-12 mental component.
Conclusion:
Men treated with PEA are more likely to improve their quality of life regarding mental health, compared with women.
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