Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

170
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
170

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sample quality criteria.

Journal of AOAC International·2015
Same author

Theory of sampling: four critical success factors before analysis.

Journal of AOAC International·2015
Same author

A systematic approach to representative sampling- sampling quality criteria, material properties, theory of sampling.

Journal of AOAC International·2015
Same journal

Correction to: Determination of Alkaloids in Mitragyna speciosa (Kratom) Raw Materials and Dietary Supplements by HPLC-UV: Single-Laboratory Validation, First Action 2017.14.

Journal of AOAC International·2026
Same journal

Single-Laboratory Validation of Simultaneous Determination of Aflatoxins in Nutraceuticals following immune-affinity Column Cleanup and Liquid Chromatography Tandem Mass Spectrometry Analysis.

Journal of AOAC International·2026
Same journal

Determination of Bromoform in Seaweed, Oil, and Animal Feed by GC-MS/MS: AOAC Official Method 2026.01, First Action.

Journal of AOAC International·2026
Same journal

ICRF-Assisted Box-Behnken Design and Optimization for Rapid UPLC-PDA Determination of Dorzolamide Hydrochloride and Timolol Maleate in an Ophthalmic Preparation.

Journal of AOAC International·2026
Same journal

Advancing PFAS Analysis Through Scientific Publication.

Journal of AOAC International·2026
Same journal

A Green UPLC-UV Method for L-Ascorbic Acid Determination Based on a Biodegradable Chelating Agent and Synergistic Hydrophobic-Electrostatic Interactions.

Journal of AOAC International·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
10:01

Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays

Published on: April 23, 2012

18.9K

Critical practicalities in sampling for mycotoxins in feed.

Claas Wagner

    Journal of AOAC International
    |March 26, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Accurate mycotoxin sampling is crucial for food safety and economic reasons. This study provides practical guidance on sampling protocols and heterogeneity characterization for mycotoxins, improving regulatory compliance.

    More Related Videos

    ELIME Enzyme Linked Immuno Magnetic Electrochemical Method for Mycotoxin Detection
    12:11

    ELIME Enzyme Linked Immuno Magnetic Electrochemical Method for Mycotoxin Detection

    Published on: October 23, 2009

    14.8K
    Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
    08:56

    Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

    Published on: November 22, 2024

    1.7K

    Related Experiment Videos

    Last Updated: Apr 15, 2026

    Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
    10:01

    Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays

    Published on: April 23, 2012

    18.9K
    ELIME Enzyme Linked Immuno Magnetic Electrochemical Method for Mycotoxin Detection
    12:11

    ELIME Enzyme Linked Immuno Magnetic Electrochemical Method for Mycotoxin Detection

    Published on: October 23, 2009

    14.8K
    Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
    08:56

    Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

    Published on: November 22, 2024

    1.7K

    Area of Science:

    • Food Science
    • Analytical Chemistry
    • Agricultural Science

    Background:

    • Mycotoxins, like aflatoxin B1, pose significant health and economic risks.
    • Current sampling guidelines partially align with the Theory of Sampling but lack practical details.
    • Accurate sampling is vital for trace concentrations and irregularly distributed mycotoxins.

    Purpose of the Study:

    • To address the lack of practical guidance in mycotoxin sampling.
    • To provide methods for heterogeneity characterization in sampling protocols.
    • To improve the representativeness of mycotoxin analysis in feed and foodstuffs.

    Main Methods:

    • Explanation of critical practicalities for sampling mycotoxins in feed decision units.
    • Guidelines for the design and use of sampling and mass reduction devices.
    • Structural guidelines for experimental heterogeneity characterization.

    Main Results:

    • Presents methods for evaluating sampling representativeness.
    • Enables determination of the optimal number of increments for composite samples.
    • Demonstrates practical application through variographic analysis and replication experiments.

    Conclusions:

    • Enhanced sampling protocols are essential for accurate mycotoxin monitoring.
    • Heterogeneity characterization is critical for valid sampling and validation.
    • The study provides practical tools for improving mycotoxin analysis in feed components.