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Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study
Damien Drubay1, Sylvaine Caër-Lorho, Pierre Laroche
1a Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LEPID, Fontenay-aux-Roses, France.
Radiation Research
|March 26, 2015
Summary
Radon exposure significantly increases cerebrovascular disease mortality risk in French uranium miners. Standard circulatory disease risk factors did not substantially alter this association, suggesting radon
Area of Science:
- Occupational Health
- Epidemiology
- Environmental Health
Background:
- Previous studies linked radon exposure to cerebrovascular disease (CeVD) mortality in French uranium miners.
- Risk factors for circulatory system diseases (CSD) in this cohort were not previously analyzed.
Purpose of the Study:
- To investigate the influence of CSD risk factors on the association between occupational radiation exposure and CSD mortality.
- To update analyses in the French uranium miner cohort through 2007.
Main Methods:
- A nested case-control study within an updated French uranium miner cohort (n=5,086).
- Individual CSD risk factor data collected from medical files for deceased cases and controls.
- Cox proportional hazard models used to assess exposure-risk relationships.
Main Results:
- Significant increases in CSD and CeVD mortality risks were associated with radon exposure (per 100 working level months).
- Hazard ratios for CSD and CeVD mortality increased with radon exposure.
- Adjusting for standard CSD risk factors did not substantially change the observed exposure-risk relationships.
Conclusions:
- The significant association between radon exposure and CeVD mortality in French uranium miners appears independent of common CSD risk factors.
- Further investigation with larger subsamples is recommended to confirm these findings.
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