Related Experiment Video
Updated: Apr 15, 2026

Transplantation Into the Mouse Ovarian Fat Pad
Published on: September 7, 2016
Expression of RASSF1A in epithelial ovarian cancers
1Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. zsl0909@sina.com.
Objective:
Ovarian cancer is the third most common cancer in female reproductive system. But ovarian cancer is hard to detect at early phase. It is very urgent to develop effective early diagnosis method for ovarian cancer. RASSF1A (Ras association domain family 1 isoform A) is a tumor suppressor, which modulates multiple apoptotic and cell cycle checkpoint pathways. We amed to find out the relationship between RASSF1A and ovarian cancer.
Methods:
We compared the expressions of RASSF1A gene in different ovarian cancer cell lines, and also in epithelial ovarian cancer tissues and normal ovarian tissues through RT-PCR (reverse transcription polymerase chain reaction) technique.
Results:
RASSF1A was expressed in HO8910 and HO8910PM cells, while RASSF1A mRNA was absent in SKOV-3 and OVCAR-3 cells. RASSF1A was expressed in 10 normal ovarian tissue samples (10/10, 100%), while RASSF1A was only expressed in 2 ovarian cancers tissue samples (2/47, 4.3%). The difference in the frequency was significant in tissue samples (100% vs. 4.3%, p < 0.05).
Conclusions:
RASSF1A could be served as a potential molecular marker for diagnosing ovarian cancer at early phase.
More Related Videos
Related Concept Videos
The Ras Gene
Ras is a...
Abnormal Proliferation
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
The Ras Gene

