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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Therapies02:49

Cancer Therapies

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Updated: Apr 15, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Developing clinical research incentives for academic oncologists.

Randall F Holcombe, Krista Hollinger

    The Journal of Medical Practice Management : MPM
    |March 27, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Incentive plans can boost academic oncologists' clinical research efforts by rewarding faculty for enrolling patients in trials. Stable, activity-indexed funding is key for sustained clinical research promotion.

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    Area of Science:

    • Oncology
    • Clinical Research
    • Healthcare Administration

    Background:

    • Academic oncologists face challenges in dedicating time to clinical research.
    • Patient enrollment in clinical trials is vital for advancing cancer treatment.
    • Existing reimbursement structures primarily focus on clinical activities.

    Purpose of the Study:

    • To propose a framework for incentive plans for academic oncologists.
    • To encourage faculty involvement in clinical research activities.
    • To ensure sustainable resource allocation for research incentives.

    Main Methods:

    • Developing structured incentive plans.
    • Defining incentivized activities and expectations.
    • Establishing stable, activity-indexed resource allocation.

    Main Results:

    • Incentive plans can effectively promote clinical research engagement.
    • Clear guidelines and stable funding are crucial for program success.
    • A model for incentivizing research, similar to clinical reimbursement, is feasible.

    Conclusions:

    • Implementing well-designed incentive plans can significantly increase clinical trial enrollment.
    • Sustainable funding models tied to research activity are essential.
    • Integrating research incentives with existing clinical reimbursement can streamline adoption.