[Tumors in paleopathology: evidences from mummies]
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Updated: Apr 15, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Valentina Giuffra1, Gino Fornaciari
1Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Divisione di Paleopatologia, Storia della Medicina e Bioetica, Università di Pisa, Pisa, I. v.giuffra@med.unipi.it
Abstract:
The relative abundance of neoplastic lesions documented so far in paleopathological literature, distributed over a wide lapse of time and in different geographic areas, demonstrates that a number of tumours affected past populations. Nevertheless, if dozens of cases of tumors affecting the skeleton are reported, only afew records are documented in soft tissues. The rarity of tumors in mummies is a debated problem; short life span of past populations, scarcity of mummified remains arrived to us in comparison with skeletal remains and technical difficulties to detect neoplastic lesions in ancient tissues seem to be the main reasons of the rarity of findings. It is important to pay maximum attention to any little sign of neoplastic lesion in ancient human remains, in order to increase our limited knowledge about the type of tumours and relative incidence afflicting our ancestors. Comparison with modern data could help understand the evolution patterns of cancer in the history of Mankind.

