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(-)-Tarchonanthuslactone exerts a blood glucose-increasing effect in experimental type 2 diabetes mellitus
Gabriela F P de Souza1, Luiz F T Novaes2, Carolina M Avila3
1Laboratory of Cell Signaling, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-761 Campinas, São Paulo, Brazil. hbee_quimica@yahoo.com.br.
Abstract:
A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative and is present only in diabetic mice. In lean, glucose-tolerant mice, despite a slight increase in blood glucose levels, the effect was not significant.
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