Prognostic implication of CD57, CD16, and TGF-β expression in oral squamous cell carcinoma
Nasim Taghavi1, Sara Bagheri2, Alireza Akbarzadeh3
1Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background:
Natural killer (NK) cells are important immune effector cells against tumors especially in the absence or reducing MHC class I antigen. Downregulation of CD16 receptor is accompanied by decreasing NK cell-killing activity. It has also been shown that some of tumor cells can evade from immune system through producing transforming growth factor beta (TGF-β) and affect prognosis. The objective of this study was to evaluate the prognostic significance of CD57(+) and CD16(+) cells and TGF-β expression in samples of oral squamous cell carcinoma (OSCC).
Methods:
CD57, CD16, and TGF-β expressions were examined immunohistochemically in 57 cases of OSCC. The relationship between markers' expression and clinicopathologic data using bivariate and multivariate analysis was assessed.
Results:
Multivariate analysis revealed that CD57 expression [HR 17.34 (95% CI 3.815-78.830); P < 0.001] and mode of invasion [HR 0.362 (95% CI 0.138-0.947); P = 0.038] correlated with survival rate, but no relation between CD57 expression and mode of invasion was seen (P = 0.96). Furthermore, no correlation between CD57, CD16, and TGF-β expression was found.
Conclusion:
These findings suggest that CD57 expression and mode of invasion are independent prognostic factors of survival in OSCC patients.
Insights
CD57 expression and mode of invasion are key indicators for predicting survival in oral squamous cell carcinoma (OSCC) patients, independent of other immune markers. This finding aids in understanding OSCC prognosis.
Area of Science:
- Immunology
- Oncology
- Pathology
Background:
- Natural killer (NK) cells are crucial for anti-tumor immunity, particularly when MHC class I is reduced.
- Decreased CD16 receptor expression on NK cells correlates with diminished cytotoxic activity.
- Tumor cells can evade immune surveillance by producing transforming growth factor beta (TGF-β), impacting patient prognosis.
Purpose of the Study:
- To investigate the prognostic value of CD57 and CD16 positive cells and TGF-β expression in oral squamous cell carcinoma (OSCC).
- To determine the relationship between these markers and clinicopathological features in OSCC.
Main Methods:
- Immunohistochemical analysis of CD57, CD16, and TGF-β expression in 57 OSCC samples.
- Bivariate and multivariate analyses were employed to assess correlations with clinicopathological data and survival.
Main Results:
- Multivariate analysis identified CD57 expression (HR 17.34, P < 0.001) and mode of invasion (HR 0.362, P = 0.038) as significant predictors of survival in OSCC.
- No significant correlation was observed between CD57 expression and mode of invasion (P = 0.96).
- No correlation was found between CD57, CD16, and TGF-β expression.
Conclusions:
- CD57 expression and mode of invasion are independent prognostic factors for survival in oral squamous cell carcinoma.
- These markers can aid in predicting patient outcomes in OSCC.
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