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Plasma H2S predicts coronary artery lesions in children with Kawasaki disease
Insights
Plasma hydrogen sulfide (H2S) is a potential biomarker for predicting coronary artery lesions in children with Kawasaki disease (KD). Lower H2S levels in acute KD patients may indicate a higher risk of coronary artery damage.
Area of Science:
- Biochemistry
- Pediatrics
- Cardiology
Background:
- Kawasaki disease (KD) is a critical pediatric illness.
- Coronary artery lesions (CAL) are a major complication of KD.
- Identifying biomarkers for CAL prediction in KD is crucial.
Purpose of the Study:
- To investigate plasma hydrogen sulfide (H2S) as a predictive biomarker for CAL in children with KD.
- To assess the correlation between H2S levels and the presence of CAL in acute KD.
Main Methods:
- Prospective study involving 50 KD patients and 27 healthy controls.
- Plasma H2S levels were measured during the acute phase of KD using a sensitive electrode method.
- Receiver operating characteristic (ROC) curve analysis was employed to evaluate predictive performance.
Main Results:
- Plasma H2S levels were significantly lower in acute KD patients compared to controls.
- KD patients with CAL exhibited lower plasma H2S levels than those without CAL.
- A plasma H2S cut-off of 31.2 µmol/L showed 81% sensitivity and 62.5% specificity for predicting coronary injuries.
Conclusions:
- Plasma H2S is a potentially valuable biomarker for predicting coronary artery lesions in children with Kawasaki disease.
- Acute-phase plasma H2S levels can aid in identifying KD patients at risk for CAL.
Background:
The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD).
Methods:
A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2 S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out.
Results:
Plasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children.
Conclusion:
Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.
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