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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Methods of genomic competency integration in practice.

Jean Jenkins1, Kathleen A Calzone, Sarah Caskey

  • 1Kappa, Clinical Advisor, National Institutes of Health, National Human Genome Research Institute, Division of Policy, Communications, and Education, Genomic Healthcare Branch, Bethesda, MD.

Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing
|March 27, 2015
PubMed
Summary
This summary is machine-generated.

Nursing champions can drive genomic integration in healthcare. Comprehensive training is essential for these champions to effectively implement genomic education and improve nursing capacity, ultimately enhancing patient outcomes.

Keywords:
Championscompetencyeducationgenomicsnursing

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Area of Science:

  • Genomic education and nursing practice integration.
  • Healthcare workforce development in genomics.

Background:

  • Genomics is increasingly vital in healthcare, requiring nurses to develop new competencies.
  • Existing knowledge gaps in nursing hinder the integration of genomic information into patient care.

Purpose of the Study:

  • To develop, implement, and evaluate a year-long genomic education intervention for nursing champions.
  • To enhance nursing capacity for integrating genomics into practice through trained and supported institutional champions.
  • To assess program satisfaction and institutional outcomes of the genomic education intervention.

Main Methods:

  • A longitudinal study involving 23 Magnet Recognition Program® Hospitals (21 intervention, 2 control).
  • Champion dyads received training via an in-person meeting and monthly webinars.
  • Institution-specific action plans were developed, updated quarterly, and progress validated through virtual site visits.

Main Results:

  • Significant variation observed in champion dyad interventions due to the complexity of genomic content and institutional factors.
  • Descriptive data analysis using content analysis revealed diverse strategies employed by champion dyads.

Conclusions:

  • Nursing champions can effectively facilitate changes in genomic nursing capacity.
  • Substantial training is crucial for champions to design and implement successful genomic integration interventions.
  • Genomic knowledge is critical for all nurses, offering opportunities to improve patient outcomes through education, policy, and service enhancements.