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Effects of Antitumor Drug Sorafenib on Chick Embryo Development
Yi-Sen Cheng1, Xiao-Yu Wang1, Guang Wang1
1Division of Histology and Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou, 510632, China.
Abstract:
Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.
Insights
Sorafenib, an anti-cancer drug, was tested on chick embryos. It affected cell proliferation, apoptosis, and neural crest cell development, indicating potential developmental toxicity.
Area of Science:
- Developmental biology
- Pharmacology
- Cancer research
Background:
- Sorafenib is an oral anti-cancer drug.
- Its in vivo pharmacological effects require further investigation.
- Tumor and embryonic cells share similarities.
Purpose of the Study:
- To investigate the effects of sorafenib on the development of gastrulating chick embryos.
- To assess sorafenib's impact on embryonic cell proliferation, apoptosis, and neural crest cell development.
Main Methods:
- Exposure of gastrulating chick embryos to sorafenib.
- Analysis of embryonic cell proliferation and apoptosis.
- Detection of interference with epithelial-mesenchymal transition (EMT).
- Assessment of neural crest cell production and migration.
Main Results:
- Sorafenib exposure significantly affected embryonic cell proliferation and apoptosis.
- Sorafenib interfered with epithelial-mesenchymal transition (EMT).
- Sorafenib impaired neural crest cell production and migration.
Conclusions:
- Sorafenib exhibits developmental toxicity in chick embryos.
- The drug impacts fundamental developmental processes like EMT and neural crest cell formation.
- Findings suggest potential risks of sorafenib during embryonic development.
