Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.3K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.3K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.4K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.4K
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

931
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
931
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

863
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
863
Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

8.5K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term outcome after segmental colonic resection for slow transit constipation.

International journal of colorectal disease·2019
Same author

Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Randomized clinical trial comparing collagen plug and advancement flap for trans-sphincteric anal fistula.

The British journal of surgery·2017
Same author

Inadvertent completely HLA-mismatched allogeneic unrelated bone marrow transplant: lessons learned.

Bone marrow transplantation·2016
Same author

Role of icodextrin in the prevention of small bowel obstruction. Safety randomized patients control of the first 300 in the ADEPT trial.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2016
Same author

Nitric oxide regulation of migrating motor complex: randomized trial of N(G)-monomethyl-L-arginine effects in relation to muscarinic and serotonergic receptor blockade.

Acta physiologica (Oxford, England)·2015

Related Experiment Video

Updated: Apr 15, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

15.3K

Results after sacral nerve stimulation for chronic constipation.

W Graf1, A-C Sonesson, B Lindberg

  • 1Institution of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Neurogastroenterology and Motility
|March 27, 2015
PubMed
Summary

Sacral nerve stimulation (SNS) shows limited effectiveness for chronic constipation. Only a small percentage of patients experienced sustained symptom relief after a trial period, suggesting it

Keywords:
constipationoutlet obstructionsacral nerve stimulationslow transit constipation

More Related Videos

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

3.3K
Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

9.0K

Related Experiment Videos

Last Updated: Apr 15, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

15.3K
Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

3.3K
Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

9.0K

Area of Science:

  • Gastroenterology
  • Neurology
  • Urology

Background:

  • Sacral nerve stimulation (SNS) is a recognized therapy for fecal incontinence.
  • Preliminary studies indicated potential benefits of SNS for chronic constipation.

Purpose of the Study:

  • To evaluate the efficacy of sacral nerve stimulation (SNS) in patients with chronic constipation.
  • To determine the long-term outcomes of SNS for refractory constipation.

Main Methods:

  • A 3-week external test stimulation of the sacral nerve was administered to patients with slow transit or outlet obstruction constipation.
  • Symptomatic improvement was assessed using bowel movement frequency and the validated Obstructed Defecation Score (ODS).
  • Permanent implantation was considered for patients achieving at least a 50% reduction in symptoms.

Main Results:

  • Out of 44 patients, 15 met the criteria for permanent implantation after the test period.
  • Four patients with permanent implants required explantation.
  • Sustained symptom relief was reported by only 5 patients (11%) at a mean follow-up of 24 months.
  • The mean ODS score showed no significant change throughout the treatment period.

Conclusions:

  • Sacral nerve stimulation (SNS) demonstrates limited efficacy in unselected chronic constipation patients.
  • Routine use of SNS for chronic constipation is not recommended based on current findings.