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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
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Evaluation of autoimmune thyroid disease in melasma
Majid Rostami Mogaddam1, Manouchehr Iranparvar Alamdari2, Nasrollah Maleki3
1Department of Dermatology, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Journal of Cosmetic Dermatology
|March 27, 2015
Summary
Women with melasma show a higher prevalence of thyroid dysfunction and autoimmunity. This suggests a potential link between thyroid conditions and this common skin hyperpigmentation disorder.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Melasma is a common acquired hyperpigmentation disorder.
- The relationship between melasma and thyroid autoimmunity is not well-established.
Purpose of the Study:
- To investigate the prevalence of thyroid dysfunction and autoimmunity in women with melasma.
- To compare thyroid profiles between women with melasma and healthy controls.
Main Methods:
- A case-control study involving 70 women with melasma and 70 age-matched healthy controls.
- Evaluation of thyroid hormone profiles and anti-thyroid peroxidase (anti-TPO) antibodies.
- Statistical analysis using SPSS software.
Main Results:
- A significantly higher prevalence of thyroid disorders (18.5%) and positive anti-TPO antibodies (15.7%) was observed in women with melasma compared to controls (4.3% and 5.7%, respectively).
- The difference in thyroid dysfunction prevalence between groups was statistically significant (P = 0.008).
Conclusions:
- A significant association exists between thyroid autoimmunity and melasma.
- Further high-quality research is necessary to confirm these findings and guide clinical recommendations for thyroid screening in melasma patients.
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