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Related Concept Videos

Patient-centered Care01:13

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Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
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SBAR I: Understanding the Concept01:29

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Effective communication among healthcare professionals during hand-off reporting is essential to delivering safe and continuous patient care. Common professional interactions include reports to healthcare team members, hand-off, and transfer reports. Nurses routinely report information to other healthcare team members and also urgently contact healthcare providers to report changes in patient status.
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Nursing Clinical Information System01:27

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Nursing Clinical Information System (NCIS)
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SBAR II: Application of SBAR01:14

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SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
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Donning PPE must be completed before contact with the patient. This process protects from infectious agents. The sequence and action included in each donning are critical, and the steps must be systematic to avoid exposure to pathogens. The institutional policy also needs to be followed while donning PPE. The pre-donning preparations are gathering equipment, inspecting the PPE equipment for tears, holes, or damage, removing jewelry, removing any garments below the elbows, and tying the hair...
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Related Experiment Video

Updated: Apr 15, 2026

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The Signature Program: Bringing the Protocol to the Patient.

B P Kang1, E Slosberg1, S Snodgrass1

  • 1Novartis Pharmaceuticals, East Hanover, New Jersey, USA.

Clinical Pharmacology and Therapeutics
|March 27, 2015
PubMed
Summary
This summary is machine-generated.

Genomic analysis drives personalized medicine in oncology, enabling targeted therapies by identifying genetic abnormalities in tumors. This approach accounts for tumor heterogeneity and shared molecular drivers across different cancer types.

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Area of Science:

  • Oncology
  • Genomics
  • Personalized Medicine

Background:

  • The deciphering of the human genome in 2004 revolutionized early-phase clinical development in oncology.
  • Genomic analysis has become a cornerstone for understanding tumor biology and developing novel therapeutic strategies.
  • Personalized medicine leverages genetic insights to tailor treatments to individual patients.

Purpose of the Study:

  • To highlight the impact of genomic analysis on the evolution of early-phase oncology clinical development.
  • To emphasize the role of identifying genetically disrupted pathways in driving targeted therapy development.
  • To discuss the implications of tumor genetic heterogeneity and shared molecular drivers for treatment strategies.

Main Methods:

  • Genomic analysis of patient tumors.
  • Identification of genetically disrupted pathways.
  • Characterization of tumor genetic heterogeneity.
  • Analysis of molecular drivers across different tumor types.

Main Results:

  • Genomic analysis has significantly advanced the development of targeted therapies in oncology.
  • Understanding genetic abnormalities is crucial for effective personalized medicine.
  • Tumors frequently exhibit genetic heterogeneity, presenting complex therapeutic challenges.
  • Identical molecular drivers can be found in tumors originating from different tissues.

Conclusions:

  • Genomic insights are fundamental to modern oncology drug development.
  • Targeted therapies, informed by genetic profiling, offer a path towards personalized cancer treatment.
  • Addressing tumor heterogeneity and shared molecular drivers is key for future therapeutic advancements.