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Updated: Apr 15, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
On being less tolerant: enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell
Alexander M Lesokhin1, Margaret K Callahan2, Michael A Postow2
1Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA. lesokhia@mskcc.org.
Abstract:
The recent approvals of two drugs that block the function of the immune checkpoint programmed cell death 1 (PD-1) have firmly planted tumor immunotherapy in the mainstream of clinical oncology. We provide a historical and immunologic context for these recent advances and discuss translational studies that provide insight into the efficacy of cancer immunotherapy at the individual patient level.
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