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Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Vasopressin: the missing link for preeclampsia?

Jeremy A Sandgren¹, Sabrina M Scroggins², Donna A Santillan³

¹Departments of Pharmacology.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

|March 27, 2015

Summary

Arginine vasopressin (AVP) may be the missing link in preeclampsia, a serious pregnancy disorder. Early increases in AVP may connect initial events to later pregnancy complications.

Keywords:

copeptin hypertension preeclampsia pregnancy vasopressin

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Last Updated: Apr 15, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Published on: August 2, 2017

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

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Published on: November 8, 2024

Area of Science:

Obstetrics and Gynecology
Cardiovascular Research
Reproductive Immunology

Background:

Preeclampsia is a major pregnancy complication affecting 5-7% of pregnancies globally.
It leads to significant maternal and infant mortality.
Current understanding lacks a clear link between initiating events and pathogenic mechanisms.

Purpose of the Study:

To investigate the role of arginine vasopressin (AVP) as a potential mechanistic link in preeclampsia.
To explore the connection between early pregnancy events and later preeclampsia development.

Main Methods:

Measured maternal plasma copeptin concentrations, a marker of AVP release, in preeclampsia.
Utilized a mouse model with chronic AVP infusion during pregnancy.

Main Results:

Demonstrated early and sustained increases in maternal plasma copeptin in preeclampsia.
Chronic AVP infusion in mice replicated key maternal and fetal symptoms of preeclampsia.

Conclusions:

Elevated AVP is identified as a potential early contributor to preeclampsia.
AVP may bridge the gap between initial triggers and the development of pregnancy dysfunctions.