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Mast cells and oral pathologies: A Review
Reet Kamal1, Parveen Dahiya2, Niti Goyal2
1Department of Oral and Maxillofacial Pathology, Himachal Pradesh Government Dental College, Shimla, India.
Mast cells (MCs), crucial for inflammation, show altered numbers in various oral diseases. This review explores these changes and MCs' roles in conditions like oral cancer and lichen planus.
Area of Science:
- Oral pathology
- Immunology
- Cell biology
Background:
- Mast cells (MCs) are key immune cells found in oral tissues.
- They contain granules with histamine and heparin, influencing inflammation.
- MCs are strategically located near oral micro-vascular endothelial cells.
Purpose of the Study:
- To review alterations in mast cell numbers in oral pathological conditions.
- To elucidate the probable roles of mast cells in these diseases.
Main Methods:
- Literature review of studies on mast cells in oral pathology.
- Analysis of mast cell counts and their correlation with disease states.
Main Results:
- Mast cell numbers are significantly altered in various oral pathologies.
- Observed changes in MCs are linked to conditions including oral pyogenic granuloma, oral lichen planus, leukoplakia, oral squamous cell carcinoma, and periapical cysts.
Conclusions:
- Mast cell counts are indicative of inflammatory processes in oral diseases.
- Understanding MC alterations is vital for diagnosing and managing oral pathological conditions.
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