Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioid hypofunction in Parkinson's disease.

R Sandyk, M A Gillman

    Medical Hypotheses
    |February 1, 1985
    PubMed
    Summary

    Parkinson's disease involves loss of dopamine neurons. This study shows evidence for reduced opioid system function, suggesting a new target for Parkinson's disease research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tobacco cessation and new indications for N2O/O2 sedation.

    SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging·2008
    Same author

    Psychotropic analgesic nitrous oxide for alcoholic withdrawal states.

    The Cochrane database of systematic reviews·2007
    Same author

    Most effective method in routine conscious sedation for ambulatory patients.

    SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging·2004
    Same author

    Overcautiousness can be a disservice.

    SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging·2002
    Same author

    Possible role of the endogenous opioid system in the placebo response in depression.

    The international journal of neuropsychopharmacology·2002
    Same author

    Psychotropic analgesic nitrous oxide (PAN) for hyperactivity.

    The Australian and New Zealand journal of psychiatry·2001

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Neurology

    Background:

    • Parkinson's disease is characterized by the loss of dopaminergic neurons.
    • Other neurotransmitter systems are also affected in Parkinson's disease.
    • A link between opioid and dopamine systems has recently been established.

    Purpose of the Study:

    • To investigate the role of the opioid system in Parkinson's disease.
    • To provide evidence for opioid system dysfunction in Parkinson's disease.

    Main Methods:

    • The study examined the function of the opioid system in the context of Parkinson's disease.

    Main Results:

    • Evidence suggests a hypofunction of the opioid system in Parkinson's disease.
    • This finding complements the known dopaminergic deficit.

    Conclusions:

    • Opioid system hypofunction is implicated in Parkinson's disease.
    • This suggests the opioid system as a potential therapeutic target for Parkinson's disease.

    Related Experiment Videos