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Updated: Apr 15, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Adoption of electronic prescribing for controlled substances among providers and pharmacies
Meghan Hufstader Gabriel1, Yi Yang, Varun Vaidya
1Office of the National Coordinator for Health IT, 200 Independence Ave, SW, Ste 745H.2.5, Washington, DC 20201.
Objectives:
Electronic prescribing for Schedule II through V controlled substances was legalized in the United States by the Drug Enforcement Administration in June 2010. However, little information exists about adoption and use of the electronic prescribing of controlled substances (EPCS) at the national level. Therefore, the objective of this study is to present the first information about national trends surrounding the adoption and use of the newly allowed EPCS by providers and pharmacies in the United States.
Study Design:
Trends of EPCS adoption and use were examined for the number of EPCS, number of pharmacies enabled to accept EPCS, and the number of providers prescribing controlled substances electronically.
Methods:
Using nationally representative transactional Surescripts data from July 2012 to December 2013, we examined EPCS trends.
Results:
During the study period, the total number of EPCS increased from 1535 to 52,423, and the number and percentage of all pharmacies enabled for EPCS increased from 8768 (13%) to 20,498 pharmacies (30%). The proportion of all providers prescribing controlled substances electronically is currently 1%, but increasing steadily each month.
Conclusions:
There is a positive national growth for EPCS in pharmacy preparedness to accept EPCS, the number of EPCS prescriptions sent each month, and the number of providers with the ability to send EPCS.
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