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The Kidney-Gut Axis: Implications for Nutrition Care
Megan Rossi1, David W Johnson2, Katrina L Campbell3
1Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia; Translational Research Institute, Brisbane, Australia.
Summary
Patients with chronic kidney disease (CKD) exhibit gut microbiota dysbiosis, contributing to disease progression. Nutritional interventions targeting the kidney-gut axis offer new therapeutic strategies for CKD management.
Area of Science:
- Nephrology
- Gastroenterology
- Microbiology
Background:
- Chronic kidney disease (CKD) is linked to intestinal gut microbiota dysbiosis.
- This dysbiosis promotes metabolic abnormalities, inflammation, and cardiovascular disease, accelerating kidney failure.
Purpose of the Study:
- To review metabolic pathways connecting gut microbiota and CKD adverse outcomes.
- To explore novel nutritional interventions for targeting these pathways.
Main Methods:
- Literature review of studies on the kidney-gut axis in CKD.
- Analysis of metabolic pathways and the role of diet.
- Examination of therapeutic strategies including protein, fiber, prebiotics, probiotics, and synbiotics.
Main Results:
- Dysbiotic gut microbiota in CKD patients drives uremic toxin production and inflammation.
- Dietary interventions show potential for modulating the gut microbiota.
- Emerging strategies may shift CKD dietary management paradigms.
Conclusions:
- The kidney-gut axis presents therapeutic targets for CKD.
- Nutritional interventions offer a promising approach to manage CKD progression.
- Targeting gut microbiota may improve outcomes in CKD patients.
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