Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Therapy01:28

Drug Therapy

418
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
418
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

1.4K
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.5K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.5K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

574
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
574
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

3.5K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is there a beneficial dose of alcohol?

Casopis lekaru ceskych·2026
Same author

Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney.

Blood pressure·2024
Same author

Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire.

Journal of hypertension·2024
Same author

In the prevention of dementia, the focus should be on early and consistent treatment of hypertension.

Vnitrni lekarstvi·2023
Same author

Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population.

Genes·2022
Same author

New onset of diabetes mellitus and weight loss as a manifestation of pancreatic cancer.

Vnitrni lekarstvi·2022

Related Experiment Video

Updated: Apr 15, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

20.2K

[Akromegaly and pharmacotherapy].

Helena Šiprová, Miroslav Souček

    Vnitrni Lekarstvi
    |March 28, 2015
    PubMed
    Summary

    This case study shows that a combination therapy of surgery, radiation, and medication can effectively manage acromegaly, even in advanced stages. Long-term stabilization was achieved, allowing the patient to live contentedly for 10 years.

    Area of Science:

    • Endocrinology
    • Neurosurgery
    • Radiation Oncology

    Background:

    • Acromegaly is a rare, serious endocrine disorder caused by excess growth hormone (GH).
    • Effective management typically involves a multimodal approach including surgery, radiotherapy, and pharmacotherapy.
    • Early diagnosis is crucial, as advanced stages present significant treatment challenges.

    Observation:

    • This article details a challenging case of acromegaly diagnosed late, precluding complete surgical removal of the pituitary adenoma.
    • The patient underwent multiple surgical interventions (transsphenoidal and transcranial) and radiotherapy (linear accelerator and Gamma Knife).

    Findings:

    • Long-term disease stabilization was achieved through a combination of repeated surgeries, radiotherapy, and pharmacotherapy.

    More Related Videos

    An Acupoint Catgut-embedding Therapy for Treating Obesity
    04:50

    An Acupoint Catgut-embedding Therapy for Treating Obesity

    Published on: April 4, 2025

    1.9K
    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    1.5K

    Related Experiment Videos

    Last Updated: Apr 15, 2026

    Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
    07:43

    Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

    Published on: January 17, 2018

    20.2K
    An Acupoint Catgut-embedding Therapy for Treating Obesity
    04:50

    An Acupoint Catgut-embedding Therapy for Treating Obesity

    Published on: April 4, 2025

    1.9K
    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    1.5K
  • Pharmacotherapy included a somatostatin analog (octreotide) and a GH receptor antagonist (pegvisomant), with dosages adjusted based on Insulin-like Growth Factor 1 (IGF1) levels.
  • The patient has maintained a good quality of life for 10 years on contemporary treatments: Sandostatin LAR 30 mg every 3 weeks and Somavert 20 mg daily.

    • Implications:

    • This case highlights the feasibility of achieving long-term acromegaly control even with initially unresectable tumors.
    • Multimodal therapy, including advanced radiotherapy and targeted pharmacotherapy, offers a viable strategy for managing complex acromegaly cases.
    • The therapeutic approach, while intensive, was deemed ethically reasonable regarding cost-effectiveness.