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Safely treating hepatitis C in patients with HIV or hepatitis B virus coinfection

Atefeh Jafari1, Hossein Khalili, Mandana Izadpanah

  • 1Tehran University of Medical Sciences, Department of Clinical Pharmacy, Faculty of Pharmacy , Tehran , Iran.

Expert Opinion on Drug Safety
|March 28, 2015
PubMed

Insights

Direct-acting antiviral agents (DAAs) show promise for treating hepatitis C virus (HCV) coinfections, particularly with HIV. Further research is needed for safety and efficacy in patients with comorbidities and in special populations.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Direct-acting antiviral agents (DAAs) are increasingly used for Hepatitis C Virus (HCV) infections.
  • Clinical trials support DAA use in HCV-coinfected individuals.
  • This review evaluates DAA safety in patients coinfected with Hepatitis B Virus (HBV) or Human Immunodeficiency Virus (HIV).

Purpose of the Study:

  • To review the safety and efficacy of direct-acting antiviral agents (DAAs) in patients coinfected with Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) or Human Immunodeficiency Virus (HIV).

Main Methods:

  • Comprehensive literature search of prospective studies, clinical trials, and congress abstracts in English.
  • Inclusion criteria focused on safety and efficacy assessments of DAAs in HCV coinfections.

Main Results:

  • Newer DAAs have overcome limitations of older treatments for HCV/HIV coinfection, including dosing, tolerability, and drug interactions.
  • Sufficient data on DAA safety and efficacy are lacking for patients with comorbidities, and for pregnant, lactating, or pediatric populations.

Conclusions:

  • DAAs represent an advancement in treating HCV/HIV coinfection.
  • Future studies should investigate DAA safety and efficacy in specific subgroups with HCV coinfection.
  • The therapeutic role of DAAs in HCV/HBV coinfection requires further evaluation.
Abstract

Keywords:
HIVcoinfectionhepatitis B virushepatitis C virus

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