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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Development and in vitro characterization of a multiparticulate delivery system for acyclovir-resinate complex
Sunil K Jain1, Ajay Kumar1, Amrish Kumar1
1a Department of Pharmaceutics , SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University) , Bilaspur , Chhattisgarh , India.
Artificial Cells, Nanomedicine, and Biotechnology
|March 28, 2015
Summary
A novel multiparticulate delivery system using ion-exchange resin and microbeads was developed for acyclovir (ACV) to combat herpes simplex virus infections. This gastro-mucoadhesive system demonstrated controlled drug release, showing potential for treating herpes virus infections.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Antiviral Therapeutics
Background:
- Herpes viruses are significant human pathogens, second only to influenza and cold viruses in causing viral diseases.
- Effective treatments are crucial for managing these threatening infections.
Purpose of the Study:
- To develop a novel multiparticulate delivery system for acyclovir (ACV).
- To achieve a gastro-mucoadhesive effect for enhanced efficacy against herpes simplex virus.
Main Methods:
- Optimized a combination of ACV and cholestyramine resin.
- Entrapped the drug-resin complex within sodium alginate and Carbopol microbeads.
- Evaluated drug entrapment efficiency (DEE), mucoadhesion, and in vitro release in simulated gastric fluid (SGF).
Main Results:
- Characterized the polyelectrolyte complex formation using SEM, DSC, and FTIR.
- Formulations with the drug-resin complex (DRC) exhibited controlled in vitro drug release.
- Rapid drug release was observed in formulations without the DRC.
Conclusions:
- The developed DRC-entrapped microbeads show promise for treating herpes virus infections.
- This system could potentially be adapted for other antiviral drugs.
- Further in vivo studies are warranted to confirm complete clearance of herpes infections.
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