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Systemic oxidative stress could predict assisted reproductive technique outcome.
A Ahelik1, R Mändar, P Korrovits
1Department of Microbiology, Faculty of Medicine, University of Tartu, Ravila 19, Tartu, 50411, Estonia.
Journal of Assisted Reproduction and Genetics
|March 28, 2015
Summary
High oxidative stress (OxS) in both partners negatively impacts assisted reproduction technology (ART) outcomes. Measuring OxS may help identify patients needing antioxidant therapy for improved fertility and pregnancy success.
Area of Science:
- Reproductive Medicine
- Oxidative Stress Research
- Infertility Studies
Background:
- Oxidative stress (OxS) is implicated in poor outcomes for assisted reproduction technology (ART).
- Understanding OxS levels in both partners is crucial for ART success.
Purpose of the Study:
- To investigate oxidative stress (OxS) levels in couples undergoing ART.
- To correlate OxS markers with clinical conditions and ART outcomes.
Main Methods:
- Recruited 79 couples undergoing ART.
- Measured oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI).
- Recorded clinical data and ART results.
Main Results:
- OxS markers (8-OHdG, 8-EPI) correlated with clinical factors like infections, endometriosis, uterine fibroids, and smoking.
- Elevated 8-EPI levels in both partners were associated with failed pregnancy progression.
- Partner's health status significantly influenced OxS levels.
Conclusions:
- Systemic OxS in either partner can adversely affect pregnancy maintenance and outcomes.
- OxS detection in ART patients can aid in selecting candidates for antioxidant therapy.
- Improving OxS management may enhance both ART success rates and natural fertility.
