[Stress and the endogenous opioid system. III. Classification of the opioid system in the process of adaptation]

In this article the effects of stress-induced release of opioid peptides are integrated into the local (LAS) and general adaptation (GAS) syndrome. Findings are explained which plead for a participation in the LAS and AAS in the sense of a reserve mechanism for the maintenance of the homoeostasis. Three areas in which these opioid peptides possibly interact are discussed, articularly the adrenal glands because of their possible importance in effectuation of stress processes. Interactions between opioid system and catecholamines as well as of opioid peptides with substance P entitle to classify the opioid system as an effective regulator of biochemical processes in stress.