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The Mystery of High-density Lipoprotein: Quantity or Quality? Update on Therapeutic Strategies

Vasiliki Katsi, Manolis S Kallistratos, Antonios N Pavlidis

  • 1Department of Cardiology, Hippokration Hospital, Athens, Greece; Department of Cardiology, Asklepeion General Hospital, Athens, Greece; Department of Cardiology, London Chest Hospital, London, United Kingdom; Hypertension Center, Third University Department of Medicine, Athens Medical School, Sotiria Hospital, Athens, Greece; First Cardiology Department, Athens University Medical School, Athens, Greece.

Reviews in Cardiovascular Medicine
|March 28, 2015
PubMed

This review summarizes the data challenging the concept that cardiovascular protection through high-density lipoprotein (HDL) is only associated with its serum concentration. This conventional impression about its protective role now appears obsolete. New aspects of its mechanisms are revealed and novel therapeutic strategies are based on them. However, data from long-term cost-effectiveness studies of treating HDL are still needed. There is a need for biomarkers that represent the functional characteristics of HDL in order to better quantify the total cardiovascular risk.

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