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Updated: Apr 15, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Re-engineering islet cell transplantation.

Nicoletta Fotino¹, Carmen Fotino², Antonello Pileggi³

¹Cell Transplant Center, Diabetes Research Institute, University of Miami, USA; University of Pisa, Italy.

Pharmacological Research

|March 28, 2015

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Novel approaches are crucial for advancing beta cell replacement therapies in diabetes treatment. Emerging technologies aim to improve reproducibility and long-term success in cell-based therapies for diabetes.

Area of Science:

Diabetes research
Cellular therapy
Immunology

Background:

Clinical islet transplantation shows progress but requires improvement for reproducibility and long-term success.
Diabetes presents multifaceted challenges necessitating a transdisciplinary approach for effective treatment.

Purpose of the Study:

To explore emerging technologies for beta cell replacement therapies.
To address the need for enhanced reproducibility and sustained functional potency in cell-based diabetes treatments.

Main Methods:

Review of emerging technologies in beta cell replacement.
Discussion of transdisciplinary approaches targeting immunity and engraftment.

Main Results:

Identification of novel strategies to overcome limitations in current cell-based therapies.

Keywords:

Beta cells Biomaterials Cellular therapies Diabetes Implantable devices Insulin Islet transplantation Islets of Langerhans Stem cells Tissue engineering

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Last Updated: Apr 15, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

Highlighting the importance of targeting immunity and promoting engraftment for sustained beta cell function.

Conclusions:

Emerging technologies offer promising avenues for advancing beta cell replacement therapies.
A transdisciplinary approach is essential for achieving reproducible and long-lasting success in treating diabetes with cell-based therapies.